One critical factor that could be contributing to some of the symptoms you might be experiencing, such as fatigue and brain fog these symptoms is NAD+ (Nicotinamide Adenine Dinucleotide)—an essential molecule responsible for cellular energy production and mitochondrial function.
In this article, we’ll explore why NAD+ is vital for Parkinson’s management, the role of mitochondrial health, and how to naturally support NAD+ levels through diet, lifestyle, and supplementation.
What Is NAD+ and Why Is It Important for Parkinson’s Disease?
NAD+ is a coenzyme found in every cell of the body. It plays a crucial role in:
Converting nutrients into ATP (cellular energy), essential for movement and brain function.
Supporting mitochondrial function, which helps maintain dopamine-producing neurons.
Regulating oxidative stress and inflammation, which can slow Parkinson’s progression.
Repairing DNA damage, which is important for neuroprotection.
However, NAD+ levels decline with age, and research suggests that individuals with Parkinson’s Disease may experience a faster depletion of this vital molecule, leading to:
- Increased fatigue and lack of energy
- Worsened motor symptoms such as tremors and stiffness
- Cognitive decline and brain fog
Because of this, optimising NAD+ levels is a key strategy for supporting cellular energy and brain function in Parkinson’s Disease.
Looking for a personalised nutrition approach to support your energy levels? Learn more about my nutrition coaching services.
How NAD+ Supports Mitochondrial Function in Parkinson’s Disease
The mitochondria—often referred to as the powerhouses of the cell—rely on NAD+ to produce ATP (adenosine triphosphate), the body’s primary energy source.
In Parkinson’s Disease, mitochondrial dysfunction is a key contributor to:
- Fatigue and weakness – Reduced ATP production leads to low energy levels.
- Neuronal damage – Without adequate NAD+, brain cells struggle to function and survive.
- Oxidative stress – Low NAD+ levels lead to increased oxidative damage, which accelerates Parkinson’s progression.
By increasing NAD+ levels, individuals may support energy metabolism, improve muscle function, and protect brain cells from further degeneration.
How to Naturally Support NAD+ Levels
While the body produces NAD+ naturally, there are several ways to support its levels through diet and lifestyle.
1. Eat NAD+ Precursors
Certain nutrients help stimulate NAD+ production, including:
🥩 Niacin (Vitamin B3) – Found in salmon, tuna, turkey, peanuts, and whole grains.
🥑 Tryptophan – An amino acid found in eggs, turkey, and spinach that can be converted into NAD+. Tryptophan is also a precursor to serotonin (the “happy hormone”)
🥦 Riboflavin (Vitamin B2) – Found in broccoli, mushrooms, and almonds, which support NAD+ metabolism.
2. Increase Polyphenol Intake
Polyphenols are plant compounds that enhance mitochondrial function and support NAD+ recycling.
🍇 Resveratrol – Found in red grapes and blueberries.
🥬 Quercetin – Found in onions, kale, and apples.
Spring Recipe: NAD+ Boosting Salmon & Spinach Bowl
Ingredients:
- 1 wild-caught salmon fillet (rich in niacin)
- 1 cup baby spinach (high in tryptophan)
- ½ cup quinoa (contains B vitamins)
- ¼ cup blueberries (loaded with polyphenols)
- 1 tbsp extra virgin olive oil
- Juice of ½ lemon
- Sea salt & black pepper to taste
Instructions:
- Cook the quinoa according to package instructions.
- Pan-sear the salmon for 3–4 minutes per side.
- Assemble the bowl with spinach, quinoa, and blueberries.
- Drizzle with olive oil and lemon juice, season with salt and pepper.
- Enjoy a brain-boosting meal packed with NAD+ precursors!
Book Your Discovery Call for Personalised Nutrition Support
If you’re struggling with fatigue, brain fog, or energy crashes, optimising your NAD+ levels may be a game-changer. Through testing and targeted nutrition strategies, I help clients improve cellular energy and brain function with science-backed solutions.
